What is juvenile idiopathic arthritis?
Juvenile idiopathic arthritis (JIA), previously known as juvenile rheumatoid arthritis, is the most common type of arthritis in children. Arthritis is a long-term condition characterized by stiffness, swelling, and pain in the joints.
An estimated 300,000 children in the United States have a form of arthritis. Some children have arthritis for just a few months, while others have arthritis for several years. In rare cases, the condition can last a lifetime.
The exact cause of JIA isn’t known. However, researchers believe it’s primarily an autoimmune disease. In people with autoimmune diseases, the immune system can’t differentiate between the healthy cells in the body and harmful substances, such as viruses and bacteria. This causes the immune system to mistakenly attack harmless cells as though they are dangerous invaders.
In children with JIA, the immune system releases substances, mainly cytokines, that damage healthy tissues in the body. This causes inflammation and pain in the joints.
Most cases of JIA are mild, but severe cases may result in complications, such as joint damage and chronic pain. Knowing the symptoms of JIA is important for getting treatment before the condition progresses.
Treatment usually consists of decreasing inflammation, controlling pain, improving function, and preventing joint damage. This can help ensure your child maintains an active, productive lifestyle.
What are the symptoms of juvenile idiopathic arthritis?
The most common symptoms of JIA include:
- joint pain
- reduced range of motion
- warm and swollen joints
- redness in the affected area
- swollen lymph nodes
- recurrent fevers
JIA may affect one joint or multiple joints. In some cases, the condition can affect the entire body, causing a rash, fever, and swollen lymph nodes. This subtype is called systemic JIA (SJIA), and occurs in about 10 to 20 percent of children with JIA. Researchers think SJIA is an autoinflammatory disease, which is different from an autoimmune disease.
What are the types of juvenile idiopathic arthritis?
There are six types of JIA:
- systemic JIA, which affects the internal organs and one or more joints
- oligoarticular JIA, which affects four or fewer joints
- polyarticular JIA, which affects five or more joints (The protein known as rheumatoid factormay or may not be present.)
- juvenile psoriatic arthritis, which affects the joints and occurs with psoriasis
- enthesitis-related JIA, which affects where bone meets the tendons and ligaments (The genetic marker HLA-B27 is often present.)
- undifferentiated arthritis, where symptoms may span two or more subtypes or not fit any of the other subtypes
The more joints that are affected, usually the more severe the disease.
How is juvenile idiopathic arthritis diagnosed?
Your child’s doctor may be able to diagnose JIA by performing a thorough physical exam and taking a detailed medical history. They may also order various diagnostic tests, such as:
- C-reactive protein test. This test measures the amount of C-reactive protein (CRP) in the blood. CRP is a substance produced by the liver in response to inflammation. Another test that detects inflammation, the sedimentation rate, may be performed as well.
- Rheumatoid factor test. This test detects the presence of rheumatoid factor, a protein produced by the immune system. Rheumatoid factor can attack healthy tissues in the body, so the presence of this protein often indicates an autoimmune disease, such as arthritis.
- Antinuclear antibody. Like rheumatoid factor, an antinuclear antibody is a protein created by the immune system in people with an autoimmune disease. An antinuclear antibody test can show whether the protein is present in the blood.
- HLA-B27 test. This test detects a genetic marker for autoimmune diseases.
- X-ray or MRI scan. These imaging tests can be used to rule out other conditions that may be causing joint inflammation or pain, such as infections and fractures.
How is juvenile idiopathic arthritis treated?
Various treatments can effectively manage and minimize the effects of JIA. Doctors usually recommend a combination of treatments to relieve pain and swelling and to maintain movement and strength.
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) and naproxen (Aleve), are often used to reduce inflammation and swelling.
Stronger medications may also be prescribed if over-the-counter (OTC) medications aren’t effective. Aspirin might be recommended, but this is rare because the medication may cause adverse side effects in children. Never give your child aspirin without a doctor’s consent.
Other prescription medications known as biological agents might also be used to help decrease inflammation and joint damage. These include:
- abatacept (Orencia)
- rituximab (Rituxan)
- anakinra (Kineret)
- tocilizumab (Actemra)
- etanercept (Enbril)
Such medications can ease symptoms by suppressing the immune system. However, they may take several months to reach maximal benefit.
In some cases, a drug called methotrexate is used to suppress joint inflammation in children with JIA.
In severe cases of JIA, surgery may be used to replace the joints altogether. Fluids might also be extracted from the tissues to reduce inflammation, and a steroid medication may be injected into the joint.
Exercising and maintaining a healthful diet are important for everyone, but they’re especially beneficial for children who have JIA. Having your child make the following lifestyle adjustments can help them cope with their symptoms more easily and reduce the risk of complications:
Weight changes are common in children with JIA. Medications may increase or decrease their appetite, causing rapid weight gain or weight loss. In such cases, a healthful diet containing the right amount of calories can help your child maintain an appropriate body weight.
Speak with a doctor about a meal plan if your child is gaining or losing too much weight as a result of JIA.
Exercising at least three times per week can strengthen muscles and improve joint flexibility, making it easier to cope with JIA in the long run. Low-impact exercises, such as swimming and walking, are usually best. However, it’s a good idea to speak with a doctor before your child begins a new workout routine.
A physical therapist can teach your child the importance of sticking with an exercise routine and can even recommend exercises suited to their specific condition. The therapist may suggest certain exercises that can help build strength and restore flexibility in stiff, sore joints.
What are the potential complications of juvenile idiopathic arthritis?
Untreated JIA can lead to further complications. These include:
- long-term recurring pain
- joint destruction
- stunted growth
- uneven limbs
- changes in vision
- pericarditis, or swelling around the heart
What is the outlook for children with juvenile idiopathic arthritis?
Children with mild to moderate JIA can usually recover without complications. However, JIA is a long-term condition that tends to cause occasional flare-ups. Your child can expect to have stiffness and pain in the joints during these outbreaks.
Once JIA becomes more advanced, the chances of going into remission are much lower. This is why early diagnosis and treatment are critical. Prompt treatment can prevent arthritis from becoming more severe and spreading to other joints.
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